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KMID : 0615720010180030123
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Jouranl of Korean Acupuncture and Moxibustion society
2001 Volume.18 No. 3 p.123 ~ p.133
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Benefical Effect of Cordyceps Sinensis Sacc. Extract ( CSS ) on Oxidant - Induced Membrane Tpransport Dysfunction in Rabbit Renal Cortical Slices
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Abstract
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Objective : This study was undertaken to determiine whether Cordyceps sinensis Sacc. (CSS) extract exerts the protective effect against oxidant-induced alterations in membrane transport function in renal tubules.
Methods : Membrane transport fucntion was estimated by examining alterations in p-aminohippurate (PAH) uptake in rabbit renal cortical slices. For induction oxidative stress, slices were treated with an organic peroxide cumene hydroperoxide for 60 min at 37oC. Cumene hydroperoxide inhibited PAH uptake in a time dependent manner.
Results : CSS at 0.5-5% concentrations prevented cumene hydroperoxide-induced inhibition of PAH uptake. CSS at 1% also attenuated LDH release and lipid peroxidation induced by cumene hydroperoxide. When slices were treated with 0.2 mM mercury chloride, PAH uptake was inhibited and lipid peroxidation was increased. These changes by mercury were significantly prevented by CSS.
Conclusion : These results suggest that CSS prevents oxidant-induced alterations in membrane transport function in rabbit renal cortical slices. Such protective effect of CSS may be attributed to inhibition of peroxidation of membrane lipid.
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